Commissioned by Frederik’s mother, Princess Julia of Nassau, to helm an educational short film about the disease with Frederik at its center, director Mei Fa Tan said she was left “inspired” by the prince but also found it “painful to watch” him struggle with his health.

Prince Frederik of Luxembourg, who died at 22, spoke about the rare genetic disorder he navigated in a video released by The PolG Foundation he founded.

Prince Frederik, 22, was a founder and the creative director of a foundation that raised awareness of POLG disorder.