The Tigers (7-1, 3-1 American Conference) overcame a 10-point halftime deficit to beat USF 34-31 on Oct. 25 at Simmons Bank Liberty Stadium. The Bulls (6-2, 3-1) were in control for most of the game, but Memphis’ offense kicked into gear in the second half to pull out the win.

Preview the Oct. 25 matchup between the South Florida Bulls and Memphis Tigers with predictions, odds, over/under, spread, betting lines and more.

USF vs Memphis preview, prediction, and betting lines. It’s the battle to be the American Conference lead dog, with both trying to push for the College Football Playoff.

Our South Florida vs. Memphis picks, odds & expert predictions see the Tigers pulling off the home upset over the Bulls on Saturday, October 25, 2025.

No. 18-ranked South Florida (6-2, 3-1 American) saw Memphis (7-1; 3-1 American) come back from a 14-point deficit entering the fourth quarter to claim a 34-31 victory over the Bulls Saturday at Liberty Bowl Stadium in Memphis.

Which mattered little, as long as he kept his team in the College Football Playoff conversation. Today, even that’s a tenuous talking point. Leading by 14 entering the fourth quarter, the No.

Quarterback Brendon Lewis connected with Cortez Braham Jr. for a 10-yard touchdown with 1:07 remaining to give Memphis a come-from-behind 34-31 victory over No. 18 South Florida.

Memphis quarterback Brendon Lewis figures to start in Week 9 against USF despite dealing with an injury throughout the week

Few games on the Week 9 slate carry more intrigue than South Florida versus Memphis, and college football analyst David Pollack made his stance clear on See Bal

The Big 12 has five teams in the Top 25 for the first time this season, Vanderbilt earned its highest ranking in 88 years, and LSU dropped out of The Associated Press college football poll Sunday following its third loss in four games.