The Bills have the Chiefs' number in regular-season play. They are 5-1 against Kansas City in regular-season meetings since 2017 and won each of the last four matchups. It is when the stakes are at their highest that the Chiefs take control. They won each of the four playoff showdowns since Mahomes and Allen joined their respective teams.

Josh Allen and the Buffalo Bills ended their two-game losing streak in Week 9 with arguably their most dominant win of the 2025 NFL season, taking down Andy Dalton and the Carolin

With the NFL season hitting its halfway point, the Indianapolis Colts are on track to make a playoff run: Super Bowl, AFC championship odds.

Here are Bills Wire's three potential X-factors on the Bills (5-2) offense against the Chiefs (5-3): As we've seen in recent weeks, Cook can carry the load for the Bills offense. Not only that, when Cook is successful, it helps out quarterback Josh Allen and the passing game. Cook needs his touches against the Chiefs.

Chris Jones had words for the Chiefs’ latest signing. Chris Jones, top-rated defensive tackle, leads Chiefs against Bills in AFC Championship rematch. Jones praised Mike Pennel’s return, calling him “a veteran presence” and “positive energy.

The Chiefs and Bills aren't division rivals, but at this point, they might as well be. Having dominated the AFC West and AFC East throughout the decade, the clubs have faced one another in the regular season every year since 2020.