The New England Patriots are currently experiencing several injury-related issues heading into Week 5, and the interior of the team's offensive line is an area the Buffalo Bills must exploit this weekend at Highmark Stadium.

The Patriots enter Sunday’s matchup with superhero quarterback Josh Allen and the Bills at brand-new Highmark Stadium with a 1-2 record.

The Buffalo Bills will face New England Patriots quarterback Drake Maye as the star is dealing with an injury.

New England Patriots vs Buffalo Bills picks, predictions, odds, win probabilities for NFL Week 4 Sunday game on Oct. 4, 2026. Who will win game?

The Buffalo Bills took home a scrappy, 24-16 victory over the Los Angeles Chargers on Sunday. Five turnovers by the offense were overshadowed by a great showing defensively, keeping the game close to allow for a comeback win. Despite not holding a lead till the fourth quarter, the Bills stayed in it and came through in the clutch.

Buffalo Bills head coach Joe Brady announced that Keon Coleman would play on Sunday against the Los Angeles Chargers.

Bills fans already got one big halftime show at the new Highmark Stadium. Now another music star is on the way.

At 71, Tom Girot is no longer selling beer at Bills games. Buffalo’s beloved Conehead still has one wish: to celebrate a Bills championship.

The Buffalo Bills host the New England Patriots at Highmark Stadium on Oct. 4 and USA TODAY's NFL experts have locked in their picks for the action.

Patriots receive concerning injury news.