Several bacteria from the Clostridium genus produce botulinum neurotoxins—the most potent biological toxins known—that cause botulism by blocking neurotransmitter release from nerves. Typically, the ...

UPTON, NY -- By deciphering the near atomic-level structure of the catalytic domain of botulinum toxin type E -- one of seven neurotoxins that cause botulism, a disease that paralyzes victims by ...

The toxin complex with its 14 components. The toxin itself is colored pink and sits at the top of the complex. The structure consists of tens of thousands of atoms, and here we only show the surface ...

Botulinum neurotoxin (BoNT) is responsible for botulism, a clinical condition resulting in flaccid muscle paralysis and potentially death. The light chain is responsible for its intracellular toxicity ...

Botulinum toxin (BTX) injection could relieve many disorders in the maxillofacial regions. Although it could have some side effects on bones and muscles. This study investigated the effects of a ...

In a comprehensive research study, scientists have uncovered a previously unknown mechanism explaining how neurons survive botulinum neurotoxin type A (BoNT/A) exposure, despite the toxin's powerful ...

PSI researchers have discovered a surprising trick that could expand the possibilities for medical use of botulinun toxin A1, better known under the name Botox, as an active agent. They have developed ...

Researchers have identified genes encoding a previously undiscovered version of the botulinum neurotoxin in bacteria from a cow’s gut. Researchers from the Quadram Institute have identified genes ...

The Botox injections that smooth wrinkles rely on the ability of botulinum toxins from the bacterium Clostridium botulinum to block communication between cells. In the cosmetic treatment, these toxins ...

Foodborne botulism is a potentially deadly condition that’s caused by eating food contaminated with botulinum toxin, a potent toxin that attacks the body’s nervous system. The disease is incredibly ...