Glucose homeostasis is regulated systemically by hormones such as insulin and glucagon, and at the cellular level by energy status. Glucagon enhances glucose output from the liver during fasting by ...
本文聚焦糖尿病视网膜病变（DR），研究发现 CaMK2A/CREB 信号通路激活与 DR 中增强的线粒体自噬（mitophagy）和神经元凋亡相关。通过体内外实验，揭示其作用机制，为 DR 神经保护治疗提供潜在靶 ...
Here, we characterized behavioral abnormalities induced by prolonged social isolation in adult rodents. Social isolation induced both anxiety- and anhedonia-like symptoms and decreased cAMP response ...
Researchers have investigated how neuronal activity influences cAMP response element binding protein (CREB) dynamics. Osaka University-led researchers investigate how neuronal activity influences cAMP ...
Discover how CREB proteins in amygdala neurons play a role in managing fearful memories and selective amnesia in new research. A couple of weeks ago, I wrote about propranolol, a drug that can erase ...
Scientists have designed and developed novel biosensors that allow the simultaneous study of both sensory evoked neuronal activity and transcription factor dynamics. Our brains have a remarkable knack ...
Scientists know that the ravages of Alzheimer disease cripple the ability to lay down new memories, but the precise molecular dance that determines the success or failure of memory formation is still ...
本研究揭示了应激状态下棕色脂肪组织通过ADRB3-cAMP-PKA-CREB信号通路激活转录因子KLF7，从而诱导IL-6产生的新机制。研究人员通过构建脂肪细胞特异性KLF7敲除小鼠模型，结合体内外实验证实该通路 ...
Despite increasing evidence linking alcohol consumption to cancer, little is known about the biological mechanisms behind the association. A new study, published Aug. 12 in Cellular and Molecular ...
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국립암센터, 폐암 항암제 내성 조절 핵심인자 CREB 규명
[메디컬투데이=김미경 기자] 국립암센터 연구팀이 폐암을 포함한 다양한 암종에서 사용되는 백금계 항암제의 내성을 조절하는 핵심 인자인 CREB(Cyclic AMP response element-binding protein)를 발견하고 그 ...
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