Characterizing clonal evolution in blood cancers like acute myeloid leukemia (AML) is critical for understanding their mutational histories and how cell populations change during disease development.

Pancreatic ductal adenocarcinoma (PDAC) is associated with a dismal prognosis and is projected to be the second leading cause of cancer related deaths soon 1. This poor prognosis is largely attributed ...

A review examines the prevailing theory of cancer evolution. The authors highlight both practical and theoretical limitations of the clonal model of cancer evolution and propose areas for improving ...

Researchers at the RUDN Laboratory of Biology of Single Cells have studied the possibilities of DNA sequencing at the level of individual cells in patients with a rare form of childhood leukemia. The ...

$${T}_{i\to i-1}=\frac{\left(n-i\right)}{\left(1+s\right)i+\left(n-i\right)}\times \frac{i}{n}$$ $${T}_{i\to i+1}=\frac{\left(1+s\right)i}{\left(1+s\right)i+\left(n-i ...

A team led by Prof. HU Zheng from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences (CAS), in collaboration with international researchers, has unveiled a ...

AI-based predictive tool for detection of ctDNA in pancreatic adenocarcinoma using nationwide comprehensive genomic profiling data. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I ...

Clinical Utility of Molecular Tumor Board Review for Identification of Possible Germline Pathogenic Variants on Tumor Next-Generation Sequencing Reports We demonstrate dynamic evolution of resistance ...

Aortic aneurysms are characterized by abnormal enlargement of the aorta, the primary artery responsible for carrying blood from the heart. Rupture often leads to sudden death, and currently, no ...