Similar to other metazoan pathogens, Schistosoma mansoni undergoes transcriptional and developmental regulation during its complex lifecycle and host interactions. DNA methylation as a mechanism to ...

Traditional bisulfite sequencing damages DNA, while enzyme-based alternatives are inconsistent. A novel methylation analysis ...

In many organisms, including plants, nucleic acid bases and derivatives such as caffeine are transported across the plasma membrane. Cytokinins, important hormones structurally related to adenine, are ...

(Nanowerk Spotlight) Cytosine (C) modifications such as 5-methylcytosine (mC) and 5-hydroxymethylcytosine (hmC) are important epigenetic markers associated with gene expression and tumorigenesis.

Cytosine and adenine base editors (CBEs and ABEs) are promising new tools for achieving the precise genetic changes required for disease treatment and trait improvement. However, genome-wide and ...

Cytosine and adenosine base editors (CBEs and ABEs) are integral to molecular breeding, enable precise modification of single-nucleotide polymorphisms (SNPs) in plants, which are crucial for agronomic ...

Chinese scientists have found that cytosine base editors (BE3 and HF1-BE3) induce genome wide off-target mutations. Researchers from Huntsman Cancer Institute (HCI) at the University of Utah have ...

DNA methylation is a fundamental epigenetic mechanism in which a methyl group is added onto a nucleotide, commonly cytosine. DNA methylation affects many biological processes, including gene ...

Chemical structure of guanine, showing its double-ring purine structure and the functional groups involved in hydrogen bonding with cytosine. (Image: Public Domain) Guanine has the chemical formula ...

Thymine, which is often abbreviated as T or Thy, can also be referred to as 5-methyluracil. Thymine is one of the pyrimidine bases found in the nucleic acid of deoxyribonucleic acid (DNA), along with ...

Three of the five nucleobases --- molecular subcomponents of information-bearing nucleotides which make up our genetic code --- likely came from space. But the origins of two key components of RNA and ...