Accurate RNA splicing is essential for gene expression and human health, yet predicting how DNA sequence variations affect ...

In a way, sequencing DNA is very simple: There's a molecule, you look at it, and you write down what you find. You'd think it would be easy—and, for any one letter in the sequence, it is. The problem ...

In just a few decades, DNA sequencing technologies evolved from slow, manual processes to rapid, automated ones, making ...

Roche debuts Axelios, a gene sequencer targeting academic and research facilities, to compete with Illumina's dominance in ...

DNA sequencing from bulk or clonal human tissues has shown that genetic mosaicism is common and contributes to both cancer and non-cancerous disorders. However, single-cell resolution is required to ...

In the 1990s, the Human Genome Project (HGP), which aimed to map the entire ~3 billion base pairs of the human genome, clearly demonstrated the technical challenges underlying the measurement of many ...

DNA methylation is a highly studied epigenetic modification that is involved in regulating genome function and plays fundamental roles in development and disease. 1 It is linked to a broad range of ...

DNA sequencing was revolutionized after scientists discovered a new bacterium in the hot springs of Yellowstone National Park, and today it's a common research technique. This game-changing bacterium ...

Although it is an important technology for studying genomes, DNA sequencing was initially accomplished in 1977 by Frederick Sanger. Since its conception, the technology has developed rapidly. Alvaro G ...

The US Naval Research Laboratory (NRL) has developed new portable field devices that will allow soldiers to identify unknown ...

We spoke to David Klenerman, co-developer of sequencing by synthesis, to find out how his work heralded the next generation ...

Researchers at the University of Toronto have invented a new method that uses DNA sequencing to measure metabolites. This enables rapid and precise analysis of biological compounds, such as sugars, ...