aProximate TM PTCs maintain high expression of key transporters involved in drug handling, including megalin and cubilin, making them ideal for studying drug transporters and drug interactions with ...
The drug finerenone has a positive effect on patients with type 1 diabetes and chronic kidney disease. The drug reduces the ...
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New Drug Protects Mitochondria and Prevents Kidney Injury in Mice
If the drug works in people, it could prevent kidney injury in high-risk populations, or potentially even treat other ...
Data presented at Kidney Week 2025 showed single subcutaneous administration of megalin-STRIKERs resulted in increased excretion of ...
Vigabatrin is indicated as monotherapy for children with infantile spasms and as adjunct therapy for adults with refractory complex partial seizures. Vigabatrin is a racemic mixture of two enantiomers ...
Focusing on pharmacokinetic and pharmacodynamic mechanisms, Dr Erin C Berthold discusses the interactions between botanical ...
Sodium-glucose co-transporter 2 (SGLT2) inhibitors, initially developed to treat type 2 diabetes, have significant heart- and ...
The rare kidney disorder immunoglobulin A nephropathy (IgAN) has no FDA-approved therapies, but several companies large and small are vying to bring patients the first one. Roche is now firmly in the ...
Tacrolimus-mycophenolate mofetil is a good option for recipients unable to tolerate sirolimus. SAN FRANCISCO—Nephrologists should consider a switch to tacrolimus and mycophenolate mofetil (TacMMF) in ...
Credit: Shutterstock Accurate assessment of glomerular filtration rate in patients with cancer is crucial to determine drug eligibility and dosing, while balancing the risks for undertreatment and ...
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