In human cells, lengthy strands of DNA have to be carefully organized and compacted so they'll fit into the nucleus; our genome is arranged into chromosomes that have to be duplicated each time a cell ...

Which end of the kinetochore fibre shortens and whether shortening actively drives or passively permits polewards chromosome movement represent enduring problems in understanding anaphase ...

In living organisms cells divide and reproduce in two ways, mitosis and meiosis. Mitosis results in two identical daughter cells, whereas meiosis results in four sex cells. During mitotic and meiotic ...

Protein kinase signaling along the kinetochore–centromere axis is crucial to assure mitotic fidelity, yet the details of its spatial coordination are obscure. Here, we examined how pools of human Polo ...

Centromeres are the chromosomal domains at which the kinetochore, a protein complex required for the correct separation of chromosomes during mitosis and meiosis, is assembled. The incorporation of ...

Cell division is essential for the correct transmission of genetic information. Each chromosome contains a centromere, a region that plays a central role in controlling chromosome movement during cell ...

As a cell divides, its DNA -the genetic material- is duplicated and condensed into structures called chromosomes, which are carefully organized and distributed so that each daughter cell acquires a ...

The centromere of chromosomes plays a crucial role in cell division. Using the model plant Arabidopsis thaliana, an international team of researchers has investigated how two crucial proteins -- KNL2 ...

The division of cells is highly-regulated and complex process which requires the organised collaboration of a multitude of different cellular components. Although the basic principles are known, many ...