In 1985, the Nobel Prize in Physiology or Medicine was awarded to Michael Brown and Joseph Goldstein for identifying the receptor that clears LDL particles from the bloodstream. High blood levels of ...

Professor Gilbert Thompson, who has died aged 93, played a leading role in showing how “bad” cholesterol (low-density lipoprotein or LDL cholesterol) is processed by the body and how faults in this ...

T cells are highly adaptable white blood cells that protect us from infections, cancer, and other threats. To do their job, T cells must rapidly switch from a quiet resting state to an active, energy ...

Proprotein convertase subtilisin/kexin type-9 (PCSK9) is highly expressed in adult hepatocytes. PCSK9 binds to and promotes the degradation of the low-density lipoprotein (LDL) receptor, thereby ...

Alumni Endowed Professor of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine RNA viruses use a ...

Heart disease remains the world's leading cause of death, and elevated LDL cholesterol is one of its biggest drivers. Cardiovascular disease remains the leading cause of death worldwide, with elevated ...

PHILADELPHIA ­— Ten patients enrolled in the experimental drug trial, and they were the sickest of the sick. All had a genetic disorder that cranks up levels of LDL cholesterol in the blood. Known as ...

Researchers have announced a promising new oral medication capable of slashing harmful cholesterol more powerfully than standard statins, a potential breakthrough for more than 86 million Americans if ...

High levels of low-density lipoprotein (LDL) cholesterol can cause artery blockages and diseases like heart attacks and strokes. Further, it raises the risk of cardiovascular disease (CVD). Thickened ...