Using human liver samples and a mouse model of cirrhosis, researchers identified epigenetic overactivation of the inflammatory PAF–PAF-R pathway in hepatic macrophages as a key driver of liver damage.

The liver is an extraordinary organ. It detoxifies the body every day without needing a cleanse, a tea or a reset.

Assessing the toxicity of food contaminants—including carcinogenic potential—is a major challenge in evaluating the risks ...

The liver produces bile, which the intestine uses for digestion. For the transport of bile, the liver relies on a network of microscopic tubings, known as bile canaliculi, formed by liver cells called ...

Over time, this damages liver cells, triggers inflammation and contributes to fibrosis, which is the build-up of scar tissue. If scarring becomes extensive, it can progress to cirrhosis, a stage where ...

Resection of liver metastases is considered the only treatment with curative potential for patients with metastatic colorectal cancer to the liver (CRLM). However, only a minority of patients with ...

Discover how a miniature model of the human liver can help improve toxicology testing for food contaminants, reducing the ...