Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 16 (April 19, 2022), pp. 1-10 (10 pages) Allosteric modulators of G-protein-coupled receptors (GPCRs) ...

For decades, opioids have been the blunt instrument of modern pain care, powerful enough to quiet severe suffering yet risky ...

Naloxone, also known by the brand name Narcan, is one of the most important drugs in the United States’ fight against the opioid crisis. It reverses an opioid overdose nearly instantly, restarting ...

July 11 (UPI) --While scientists have long noted a complex connection between a person's addiction to opiates, or "opioid use disorder," and chronic pain, the brain mechanisms linking the two have ...

We report that opioids from the inflamed colon activate δ-opioid receptors (DOPr) in endosomes of nociceptors. Biopsy samples of inflamed colonic mucosa from patients and mice with colitis released ...

Researchers used emergent MRI technology to understand the impact of prenatal opioid exposure on early brain development and the neural mechanism behind current medications. “Choose life. Choose a job ...

INDIANAPOLIS, March 28, 2023 — There’s been a recent push in the U.S. to make naloxone — a fast-acting opioid antidote — available without a prescription. This medication has saved lives, but it’s ...

Federal officials on Thursday approved a new type of pain drug designed to eliminate the risks of addiction and overdose associated with opioid medications like Vicodin and OxyContin. The U.S. Food ...

MARSHALL - Members of the county health department appeared before the county commissioners Nov. 30 to brief the board on a potential settlement the county could receive as part of a state settlement ...