Osteoclasts are mitochondria-rich cells that rely on oxidative phosphorylation to fuel differentiation and bone resorption. Oxidative phosphorylation generates reactive oxygen species (ROS), which ...

A research team, led by Professor Sung Ho Park in the Department of Biological Sciences at UNIST announced the results of a study on osteoblasts that damage joint bones in patients with rheumatoid ...

Epigenetic alterations in peripheral blood cell DNA and implications for breast cancer detection, prognosis, and treatment. Background: Bisphosphonates (BPs) are widely used for the treatment in bone ...

Osteoblasts act in a group to make bone over the course of several months. However, how osteoblasts cooperate with each other in vivo is still unknown. Now, researchers at Osaka University established ...

Mineralization is mediated by osteoblasts, which secrete mineral precursors through matrix vesicles (MVs) as a fundamental process in vertebrates. The vesicles are calcium and phosphate rich, ...

Osteoblasts act in a group to make bone over the course of several months. However, how osteoblasts cooperate with each other in vivo is still unknown. Now, researchers at Osaka University established ...

Throughout our lives, our bones are continuously remodeled to maintain strength, repair injuries and adapt to new stresses. Bone dynamics depend on two associated cell types: osteoblasts, which are ...

Osteoblasts act in a group to make bone over the course of several months. However, how osteoblasts cooperate with each other in vivo is still unknown. Now, researchers at Osaka University established ...

A "living tissue" that supports the body and is constantly being remodeledWhen we think of bones, we imagine them as hard, immobile "pillars of the body."However, from the perspective of histology, ...

Scientists have identified a protein that blocks the activity of bone-forming cells (osteoblasts) by stopping them from maturing during the journey to sites of bone formation, a new study has found.

Researchers at Osaka University show that intercellular communication via extracellular vesicles from bone-making osteoblasts is a key factor for the switch from bone formation to resorption through a ...