Researchers at Baylor College of Medicine have discovered that certain p53 mutants hijack the DNA replication machinery ...

Fertility: Research suggests p53 may play a role in female fertility and reproductive health. Therefore, p53 is a crucial ...

The gene p53 acts as a tumor suppressor and is often called the guardian of the genome. This gene is central to maintaining genomic stability, which prevents mutations from accumulating and leading to ...

Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53) are often associated with aggressive tumor behavior and poor patient ...

Phase 0/1 of positron emission tomography (PET) imaging agent [18F]-ODS2004436 as a marker of EGFR mutation in patients with non-small cell lung cancer (NSCLC). Comparison of the tumor mutation burden ...

Sir2, an enzyme belonging to sirtuins, has been shown to be involved in the deacetylation of proteins. Researchers from the ...

The most commonly mutated gene in cancer, p53, works by shifting cell metabolism in a way that alters a cell’s identity, researchers at the Sloan Kettering Institute have discovered. More than 50% of ...

The p53 tumor suppressor gene is the most frequently mutated gene in human cancers, and germ-line p53 mutations cause a familial predisposition for cancer. Germ-line or sporadic p53 mutations are ...

Oxidative stress occurs when there are high levels of reactive oxygen species (ROS) in the body, that are capable of damaging lipids, proteins, and DNA. Oxidative stress can occur as a result of a ...

At the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Frontier Medicines Corp. presented a first-in-class covalent activator of p53 Y220C with high potency and ...