The San Francisco 49ers and Carolina Panthers are in a race for a playoff spot, but the 49ers are favored big in their Week 12 showdown on MNF.

NFL Week 12 odds, picks, predictions, TV channel, streaming information for Monday Night Football between Carolina Panthers and San Francisco 49ers.

Entering the week the 49ers are 6-4 and on the outside looking in at a playoff spot. They're the No. 8 seed, just behind the Green Bay Packers (5-3-1) and Chicago Bears (6-3). That could all look much different after the next four games where the relative "ease" many assumed their schedule would have shines through.

NBC Sports Bay Area asked the 49ers Faithful how many games San Francisco will win to close out the 2025 NFL regular season.

Arizona had the passing game working, but it didn't matter in a 41-22 loss to San Francisco at State Farm Stadium in Glendale.

What channel is San Francisco 49ers vs Arizona Cardinals game on today? How to watch NFL Week 11 football game on TV, streaming Sunday, Nov. 16, 2025.

The San Francisco 49ers welcome back Brock Purdy under center going into their game against the Arizona Cardinals. How long a leash will he get, and how do their playoff chances look?

The final selection of the 2022 NFL Draft, Purdy became the starting quarterback as a rookie after the 49ers lost Jimmy Garoppolo and Trey Lance to injuries. Purdy led San Francisco to victory in his first seven starts before sustaining his first loss in the NFC Championship Game.