In proteomics applications of tandem mass spectrometry (MS/MS), one of the core analysis challenges is the de novo sequencing problem: given an observed fragmentation spectrum, can we infer the amino ...

In just a few decades, DNA sequencing technologies evolved from slow, manual processes to rapid, automated ones, making ...

Proteins, one of the smallest building blocks of life on Earth, hold promise for answering some of biology's biggest questions. Consisting of amino acids strung together into peptide chains, these ...

Despite advances in mass spectrometry and emerging single-molecule approaches, sequencing peptides at the single-molecule level remains a central challenge in proteomics. Here we present a ‘reverse ...

A new study shows that long-read sequencing has the potential to improve the rate of diagnosis while reducing the time to diagnosis from years to days -- in a single test and at a much lower cost. One ...

One in every 10 people worldwide is impacted by a rare genetic disease but about 50% of them remain undiagnosed despite rapid increases in genetic technology and testing. Even when a person does have ...