Nat Clin Pract Neurol. 2008;4(3):159-169. Drug Primary clinical use Protective effect during administration in animal models? Effects of withdrawal in EAE Clinical study Phenytoin Treatment of ...

A novel, investigational NaV1.8 sodium channel blocker known as VX-548 reduced acute pain after abdominoplasty or bunionectomy at the highest dose, but not at lower doses, two phase II trials showed.

Neuropathic pain syndromes remain a major therapeutic challenge, despite considerable research efforts during the past few decades. Many hypotheses about the mechanisms of pain generation have been ...

A new study on live tissue cells is the first to reveal how channels that allow sodium to enter into breast cancer cells enable tumours to grow and spread. The discovery adds to evidence which ...

Neurobiologist John Wood has long been interested in how animals feel pain. His research at University College London (UCL) typically involved knocking out various ion channels important in sensory ...

Ion selectivity is an important property of cell membrane ion channels. For example, potassium ion channels are more permeable to potassium ions than to sodium ions. The mechanism underlying the ready ...