During translation, multiple ribosomes travel along the nucleic acid chain to build polypeptides that become functional proteins. Occasionally, these molecular decoders pause on the mRNA, either ...
Mitochondrial ribosomes, or mitoribosomes, are specialised organellar complexes responsible for synthesising a subset of proteins encoded by mitochondrial DNA. These proteins are critical for the ...
Protein production (translation) is a complex process involving machinery called ribosomes. How do cells counter ribosomal destabilization leading to premature termination of translation? Scientists ...
Internal ribosome entry sites (IRESs) are highly structured RNA elements that permit the recruitment of ribosomes for translation initiation independent of the conventional 5′-cap mechanism. Viruses ...
Proteins are the key players that regulate cellular structure and function. DNA, which functions as the blueprint for protein synthesis, is first transcribed into a messenger RNA (mRNA), which is ...
Ribosomes can function with iron or manganese ions in place of magnesium, recent results show, providing an insight into the evolutionary history of protein transcription. A recent study that set out ...
Global transcriptomic and proteomic analyses of T cells have been rich sources of unbiased data for understanding T-cell activation. Lack of full concordance of these datasets has illustrated that ...
In the fast-evolving field of medical science, a new artificial intelligence model may be about to change the way mRNA-based drugs and vaccines are designed. Developed through a collaboration between ...
A new technique reveals ribosome cooperativity, providing new insights into protein production. Researchers from Marvin Tanenbaum’s group at the Hubrecht Institute (Utrecht, Netherlands) have ...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a beta-CoV that recently emerged as a human pathogen and is the causative agent of the COVID-19 pandemic. A molecular framework of how ...
Infectious viruses come in many shapes and sizes and use slightly different attack mechanisms to make humans and animals sick. But all viruses share something in common: They can only do damage by ...
PHILADELPHIA, March 11, 2021 /PRNewswire/ — Researchers at Children’s Hospital of Philadelphia (CHOP) have identified genes responsible for hematopoietic stem cell (HSC) regeneration via the assembly ...
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