The Colorado Buffaloes and Arizona Wildcats clash this afternoon, in a game where both teams have lost 3 of their last four and need to right the ship heading into the back end of the season.

Louisville head coach Jeff Brohm has a score to settle when his side faces Virginia Tech on Saturday in what will be the first time these teams have met in Blacksburg since 1991.

During this week's all-domestic slate, another clash between the Buffalo Bills and Kansas City Chiefs – taking place on CBS during the late afternoon slate – is the big headliner.