For Week 16 NFL betting, SportsLine AI has evaluated the NFL odds and provided NFL betting picks for all 16 games. You can only see the AI predictions for the Week 16 NFL schedule here. After analyzing every game in Week 16, the AI says the Broncos (-3, 45.5), who have won 11 in a row, cover comfortably against the Jaguars .

Eleven games have spreads of four points or fewer, and nine home teams are catching points as underdogs. Mix in late-season motivations, banged-up rosters, along with winter weather, and escaping Week 16 could be the most impressive feat for poolies this year.

BEST BETS: Texans, Bills, Vikings. LOCK OF THE WEEK: Texans (Locks 5-9 in 2025). LAST WEEK: 5-9 overall, 0-3 Best Bets.

NFL survivor pool participants in pools with 20 gameweeks got to experience Black Thursday as well as Black Friday this year, with all four

NFL Week 16 odds, picks, predictions, TV channel, streaming information for Saturday football game between Philadelphia Eagles, Washington Commanders.

Get Athlon Sports’ expert NFL picks, predictions and betting advice for every Week 14 game, including a potential Super Bowl preview in Denver.