Western Kentucky earned its first Homecoming win since 2021… rallying past New Mexico State 35–16 behind a dominant defensive effort and four touchdowns from redshirt freshman Rodney Tisdale Jr.

At 6-2, the Western Kentucky Hilltoppers face the New Mexico State Aggies as solid favorites hoping to avoid an upset at home today.

Preview the Oct. 21 matchup between the Louisiana Tech Bulldogs and Western Kentucky Hilltoppers with predictions, odds, over/under, spread, betting lines and more.

The Western Kentucky Hilltoppers and Louisiana Tech Bulldogs meet Tuesday at Joe Aillet Stadium in Ruston, Louisiana.

WKU is 4-1 both straight up and against the spread and also enters this matchup with back-to-back covers. The Hilltoppers beat Missouri State 27-22 last time out and Nevada the prior week and they've jumped out to a 2-0 start in Conference USA play, tying them with Louisiana Tech atop the standings.

Hilltoppers stay within the spread as Maverick McIvor airs it out in our Western Kentucky vs. Louisiana Tech predictions, odds & college football picks for Tuesday, October 21.

FIU visits Western Kentucky in Week 8 of the 2025 college football season, with expert predictions, key player matchups and insights on what to expect.

For Western Kentucky, the path to success rests with the offense. Maverick McIvor leads one of the best passing attacks in the conference, but they sputtered against a talented FIU secondary.

SportsLine's model has simulated Western Kentucky vs. Louisiana Tech 10,000 times and revealed its college football bets

New Mexico State football (3-5, 1-4 CUSA) remains winless on the road this season after coming up short against Western Kentucky (6-2, 5-1 CUSA) on Saturday, 35-9. The Hilltoppers would be held scoreless in the first 26 minutes of the game,