Data sources Cochrane Central, PsycINFO, Embase, Medline and CINAHL. Eligibility criteria Peer-reviewed, randomised controlled trials, in English (1990–present), which examined the effects of exercise ...
Mutations in two highly related chromatin-remodeling complexes, BRG1/BRM-associated factor (BAF) and Polybromo-associated BAF (PBAF), cause various neurodevelopmental conditions. Although BAF activity ...
Investigators have created computer-generated models to bridge the gap between 'test tube' data about neurons and the function of those cells in the living brain. Their study could help in the ...
Teplizumab, a humanized monoclonal antibody to CD3 on T cells, is approved by the Food and Drug Administration to delay the onset of clinical type 1 diabetes (stage 3) in patients 8 years of age or ...
The failure to elucidate the complex pathophysiology of type 2 diabetes and obesity has frustrated current efforts to develop improved therapeutic and preventive strategies. The health consequences ...
Janus kinase (JAK) inhibitors, including baricitinib, block cytokine signaling and are effective disease-modifying treatments for several autoimmune diseases. Whether baricitinib preserves β-cell ...
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