Researchers at the Centre for Genomic Regulation and the Wellcome Sanger Institute have comprehensively identified the allosteric control sites found in the protein KRAS, which is one of the most ...

Researchers have comprehensively identified the allosteric control sites found in the protein KRAS. These are highly sought after targets for drug development, representing secret vulnerabilities ...

Researchers have comprehensively identified the allosteric control sites found in the protein KRAS. These are highly sought after targets for drug development, representing secret ...

Allosteric effectors have the ability to modulate protein-ligand interactions in a controlled fashion. Now a novel class of antibody-like affinity reagents, synthetic antigen binders or sABs, are ...

Ligands, including an antibiotic, control access to the active site of a key methicillin-resistant bacterial protein ...

Our next step is to create allosteric control for a variety of protein complexes by our strategy. Moreover, we will try to design novel functions into pseudo-active sites.

Here we update our understanding on the allosteric control of fiber formation at equilibrium by showing how the simplest extension of the classic quaternary two-state allosteric model of Monod, Wyman, ...

These allosteric effects are in agreement with previous folding simulations that predicted L2 could communicate with residues surrounding the metal center. Our findings suggest that long-range ...

Our next step is to create allosteric control for a variety of protein complexes by our strategy. Moreover, we will try to design novel functions into pseudo-active sites.

Antibiotics target protein synthesis by binding and inhibiting key functional centers of the ribosome. Single-molecule imaging and X-ray crystallography studies now demonstrate that the ...