“This is an exciting development for our understanding of how p53 contributes to preventing cancer development,” said study co-author Robin Fåhraeus.

A comprehensive review by researchers at Taylor’s University highlights the oncogenic role of mutant p53 (mutp53) in cancer progression and resistance to therapy. The study explores ...

Tumor Protein 53 (p53) expressed from gene TP53 is a seminal tumor suppressor. We aimed to characterize mutational and nonmutational mechanisms of p53 dysfunction in myelodysplastic syndromes (MDS) ...

The study also revealed that disrupting minor splicing triggers the p53 tumor suppressor pathway, a critical defense mechanism in the body's fight against cancer.

This activation promotes cancer cell survival and migration-particularly under stress. Therapeutic implications: Disruption of the nuclear PIPn-p53 signalosome, especially in mutant p53-driven ...