The secret to the naked mole-rats' extraordinarily long life may lie in subtle changes to just four amino acids, researchers report. According to a new study, evolutionary mutations in cGAS – an ...

In a step toward treating mitochondrial diseases, researchers in the Netherlands have successfully edited harmful mutations in mitochondrial DNA using a genetic tool known as a base editor. The ...

Despite the significance of immune checkpoint inhibitors (ICIs) in solid tumor treatment, identifying ICI-sensitive populations remains a challenge. Mutations in DNA damage response (DDR) pathway ...

Prognosis and survival evaluation in treating high-risk BRAF V600 mutation stage III or IV melanoma with dabrafenib plus trametinib therapy: A meta-analysis of 2,660 patients.

Precision gene editing is crucial for treating genetic diseases, as it enables targeted correction of specific mutations. A Korean research team has become the first in the world to significantly ...

DNA repair mechanism: HELQ helicase remodels stalled replication forks into stable structures, preventing harmful mutations under replication stress. Advanced imaging tool: RF-SIRF maps reversed forks ...

Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by ...

The work shows how DNA repair proteins bind, unwind, and rejoin strands, identifying previously unseen intermediate ...

A newly discovered molecule disrupts cancer cells’ ability to repair DNA by triggering the breakdown of key proteins. Cancer ...

Learn more about a new experimental procedure that uses cancer cells’ DNA repair system against itself to make drug-resistant ...