This valuable study substantially improves the phylogenetic framework for Kinetoplastea through greatly expanded sampling of free-living neobodonids; the phylogenomic analyses provide convincing ...

Biochemical and electrophysiological approaches show that the amphetamine derivative ECSI#6 is an uncompetitive inhibitor of the serotonin transporter and thus the first ever characterized ligand of a ...

eLife reviews plant biology research including development, epigenetics, genomics, signalling, metabolism and plant-microbe interactions. Learn more about what we review and sign up for the latest ...

eLife reviews research into cancer spanning from oncogenes and tumor suppressors to metastasis and anticancer treatments. Learn more about what we review and sign up for the latest research.

eLife reviews research in which approaches from the physical sciences are used to provide insights into the properties of biological systems and processes. Learn more about what we review and sign up ...

Crystal structures of γ-protocadherin cell-cell recognition dimers reveal the determinants of clustered protocadherin homophilic specificity and cis interaction region structures alongside mutagenesis ...

Cryo-EM structures of 70S•RelA ribosome complexes reveal how cognate deacyl-tRNA activates RelA.

This study examines an interplay between synaptic mitochondria and glutamate receptor exocytosis in C. elegans. Collectively, the solid results support the idea that mitochondrial function influences ...

A family of proteins called Toll receptors, best known for their role in the immune system, also enable the brain to change its structure in response to experience. Everything that you experience ...

To control reaching, the nervous system must generate large changes in muscle activation to drive the limb toward the target, and must also make smaller adjustments for precise and accurate behavior.

The structure of the calcium channel Orai in an open conformation reveals a dilated pore and gives insight into mechanisms of ion permeation and calcium selectivity.

Multiple learning processes contribute to successful goal-directed actions in the face of changing physiological states, biomechanical constraints, and environmental contexts. Amongst these processes, ...