It's hard to picture anyone else taking on the role.

Patrick Dempsey has revealed he had been planned to reunite with late Grey's Anatomy co-star Eric Dane on his new show, Memory of a Killer, prior to his death.

Rob Lowe explains why he declined the role of Derek Shepherd on Grey’s Anatomy, how Patrick Dempsey was cast, and what happened during the show’s early casting process ...

Fans are remembering Eric Dane's role in "Grey's Anatomy" after the actor died at 53. Look back at Mark Sloan's most iconic ...

His career took off after he emerged from a shower with a strategically placed towel on the ABC hit. Later, he starred on ...

"He was the funniest man, he was such a joy to work with and I want to just remember him in that spirit," Dempsey said after ...

Following the death of Eric Dane, here's a look at what former Grey’s Anatomy cast members are doing now.

Eric Dane opened up to PEOPLE about why he never saw himself as a 'sex symbol' while playing Dr. Mark Sloan, a.k.a. McSteamy, on 'Grey's Anatomy.' Dane died Feb. 19 at the age of 53.

Tributes are pouring in for actor Eric Dane, best known for his roles on “Grey’s Anatomy” and "Euphoria," following his death ...

Season 2 of Grey’s Anatomy saw the arrival of Eric Dane in 2006, taking the role of the charismatic yet controversial plastic ...