The Tigers (7-1, 3-1 American Conference) overcame a 10-point halftime deficit to beat USF 34-31 on Oct. 25 at Simmons Bank Liberty Stadium. The Bulls (6-2, 3-1) were in control for most of the game, but Memphis’ offense kicked into gear in the second half to pull out the win.

Our South Florida vs. Memphis picks, odds & expert predictions see the Tigers pulling off the home upset over the Bulls on Saturday, October 25, 2025.

Preview the Oct. 25 matchup between the South Florida Bulls and Memphis Tigers with predictions, odds, over/under, spread, betting lines and more.

The defeat to Miami remains the only blemish on South Florida’s ledger, and the Bulls responded to the defeat in style, winning their next four games by an average margin of 34.75 points. Three of those opponents were also-rans, but a 63-36 victory over red-hot North Texas was as impressive a performance as you’ll see in the Group of 5 this season.

Which mattered little, as long as he kept his team in the College Football Playoff conversation. Today, even that’s a tenuous talking point. Leading by 14 entering the fourth quarter, the No.

Memphis Tigers football coach Ryan Silverfield's team isn't a shoo-in for the American Championship Game, but they're the closest thing in the conference.

Few games on the Week 9 slate carry more intrigue than South Florida versus Memphis, and college football analyst David Pollack made his stance clear on See Bal

Memphis quarterback Brendon Lewis figures to start in Week 9 against USF despite dealing with an injury throughout the week

On Saturday, the USF Bulls and Memphis Tigers will tussle in an American Athletic Conference battle at Simmons Bank Liberty Stadium.