NO is known to induce expression of heme oxygenase-1, an antioxidant enzyme in blood vessels. We tested whether NO might modulate the endothelial NADPH oxidase function via heme oxygenase-1. In human ...

Diamine oxidase (DAO) is a digestive enzyme that rids your body of histamine. Histamine is a signal protein important for digestion, allergic response, immunity, and more. Experts don't agree, but ...

Abstract: This article analyzes the mitochondrial cytochrome C oxidase subunit I (COI) gene sequences and morphology of Pila to identify and understand genetic interactions. The morphology of apple ...

Prime Medicine reports positive initial Phase 1/2 trial results for PM359, showing safety and efficacy in treating Chronic Granulomatous Disease. Prime Medicine, Inc. has announced positive initial ...

-- Initiating efforts to explore continued clinical development opportunities for PM359 external to Prime Medicine -- CAMBRIDGE, Mass., May 19, 2025 (GLOBE NEWSWIRE) -- Prime Medicine, Inc. (Nasdaq: ...

This new article publication from Acta Pharmaceutica Sinica B, discusses how diabetes-associated sleep fragmentation impairs liver and heart function via SIRT1-dependent epigenetic modulation of NADPH ...

The last time I went to the doctor, I lived in a different zip code, belonged to a different body-weight category, and was rounding out a different decade. I never consciously swore off health care, ...

As a person with a chronic illness, I'm no stranger to bloodwork. I used to pore over my lab results, googling the various meanings, and trying not to panic when a test fell out of range. Function ...

Your working memory, cognitive flexibility, and self-regulation are core components of executive function (EF), an interrelated set of mental skills that lay the foundation for advanced cognitive ...

Background GWAS have linked loss-of-function mutations in phagocytic NADPH oxidase complex (NOX2) genes, including NCF1 and NCF2, to lupus pathogenesis. The prevailing model holds that reduced NOX2 ...

Introduction:: Endothelial dysfunction is the leading cause for diabetes (DM) related coronary heart disease. Diabetes is associated with NADPH Oxidase (Nox) overproduction and related ROS ...