It's hard to picture anyone else taking on the role.

Rob Lowe explains why he declined the role of Derek Shepherd on Grey’s Anatomy, how Patrick Dempsey was cast, and what happened during the show’s early casting process ...

It's a McDream come true. Patrick Dempsey's Derek Shepherd made a shocking return in the season premiere of ABC's "Grey's Anatomy," sending longtime viewers into a frenzy on Thursday night over the ...

If you haven't seen Thursday's "Grey's Anatomy" and plan to — SPOILER ALERT! Out of nowhere, the episode walloped viewers with the shocking exit of — wait for it — Derek "McDreamy" Shepherd, the ...

The hints of a Derek Shepherd replacement finally being revealed in Grey’s Anatomy season 21 make the return of one sidelined feature of the medical drama possible in season 22. Derek’s relationship ...