Thalassemia (thal-uh-SEE-mee-uh) is a blood disorder that is inherited. This means it is passed down from one or both parents through their genes. When you have thalassemia, your body makes less ...

Variations in the phenotypic expression of heterozygous beta thalassemia reflect the formation of different populations. To better understand the profile of heterozygous beta-thalassemia of the ...

CRISPR technology may soon lead to major stock growth in genomics. CRISPR therapies target diseases with genetic editing either inside or outside the body. Beam, CRISPR Therapeutics, Caribou, and ...

Unesp-Ibilce Departamento de Biologia Laboratório de Hemoglobinas e Genética das Doenças Hematológicas (LHGDH) São José do Rio Preto-SP During the last twenty years the hemoglobin laboratory in Unesp, ...

Introduction: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common X-linked hereditary disorder in southern China. However, the incidence rate of G6PD deficiency and the frequency of the ...

A new article reports two patients appear to have been cured of beta thalassemia and sickle cell disease after their own genes were edited with CRISPR-Cas9 technology. The two researchers who invented ...

Here, we describe the first two patients, one with TDT and the other with SCD, who were infused with CTX001 (autologous CRISPR-Cas9–edited CD34+ HSPCs that were genetically edited to reactivate the ...

Patients with transfusion-dependent β-thalassemia need regular red-cell transfusions. Luspatercept, a recombinant fusion protein that binds to select transforming growth factor β superfamily ligands, ...

Thalassemia is an inherited blood disorder in which the body makes an abnormal form of hemoglobin. Hemoglobin is the protein molecule in red blood cells that carries oxygen. The disorder results in ...

This is a retrospective analysis in which the risk of SSC was studied in a cohort of 122 patients affected by TM who survived for at least 3 years after an allogeneic HCT performed at the Bone Marrow ...

ABSTRACT: This study presents a compilation of results obtained by several research groups on the mutational analysis of β thalassemia in Portugal and in Morocco, and compares the mutation/haplotype ...

ABSTRACT: This study presents a compilation of results obtained by several research groups on the mutational analysis of β thalassemia in Portugal and in Morocco, and compares the mutation/haplotype ...