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١-ظهور شعر الابط والعانة Premature Pubarche قبل وحول سن الثمان سنوات فهو دليل ع نشاط الغدة الكظرية وقد يكون علامة عالاصابة المحتملة بمتلازمة تكيس المبايض! ٢-اجراء تحاليل الدم وفحص هرمونات البلوغ Activation of HPG axis والغدة الكظرية Premature Adrenarche لمعرفة ما ان تتنشطت قبل السن المحدد وهي احد علامات الاصابة بالمتلازمة. ٣-ظهور الثدي المبكر CPP وهو اول علامات البلوغ فاذا صار الم وظهور الحلمة خاصة قبل عمر ال٨ او في سن الثامنة قد ينذر بحدوث البلوغ المبكر الحقيقي وهو احد العلامات التنبؤية بالاصاب
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