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Malignant Hyperthermia vs Neuroleptic Malignant Syndrome is a high-yield differential diagnosis (your matrix/grid, bow tie type of a question). Both conditions share the same core signs and symptoms, remember HAM: • High fever (104–105°F) • Altered mental status • Muscle rigidity And both are treated with dantrolene! How do we tell them apart? We look at the cause: • Malignant Hyperthermia (MH): congenital reaction to anesthesia and neuromuscular-blocking agents • Neuroleptic Malignant
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